The invention discloses a method for efficiently removing gentamicin in gentamicin drug dregs. Through co-composting of the gentamicin drug dregs and lovastatin drug dregs, degradation of the gentamicin in the gentamicin drug dregs can be realized, contents of the gentamicin in the gentamicin drug dregs are lowered, thus reliving of imbalance of microbial population structure and great harm to human health and ecotope caused by direct discharging of the gentamicin can be realized.