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发明授权
CN106421746B [Pyr1]-Apelin-13作为长效酰胺类局麻药中毒所致心脏停搏的抢救药物的应用 有权

[Pyr1]-Apelin-13作为长效酰胺类局麻药中毒所致心脏停搏的抢救药物的应用
摘要：
本发明公开了一种[Pyr1]‑Apelin‑13作为长效酰胺类局麻药中毒所致心脏停搏的抢救药物的应用，其技术方案是该抢救药物包括有[Pyr1]‑Apelin‑13，该[Pyr1]‑Apelin‑13为肽序列为：Glp‑Arg‑Pro‑Arg‑Leu‑Ser‑His‑Lys‑Gly‑Pro‑Met‑Pro‑Phe。本发明的有益效果是：本发明提供了一种基于[Pyr1]‑Apelin‑13的抢救药物，作为可有效解救局麻药中毒所致的心脏停搏，提高复苏率。此方案采二次死亡率较之公认的脂肪乳剂联合肾上腺素使用更低,而60分钟存活率更高。
摘要（英）：

The invention discloses an application of (Pyr<1>)-Apelin-13 as a salvage drug for cardiac arrest caused by long-term amide class local anesthetics toxicity. The technical scheme includes that the salvage drug comprises (Pyr1)-Apelin-13 with the sequence to be: Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe. The application has the advantages that the salvage drug on the basis of the (Pyr<1>)-Apelin-13 can be used for effectively saving cardiac arrest caused by local anesthetic toxicity, and recovery rate is increased; secondary mortality is lower as compared with recognized use of lipid emulsion with epinephrine, and 60-minute survival rate is higher.

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