The invention relates to the field of machinery. An electrical cabinet with a grounding interlock comprises an electrical cabinet main body, wherein the electrical cabinet main body comprises a shell, the grounding interlock is arranged in the shell and comprises an interlock piece, the interlock piece is connected with a block body by a transmission mechanism, an external convex part is arranged on the block body, the block body is connected with the shell in a sliding way, an opening is formed in the shell and is used for the external convex part to extend, the interlock piece is in transmission connection with a guide rail, the guide rail is connected with a handcart in a sliding way, and a through hole is formed in the guide rail and is used for the interlock piece to extend during rotation. A user operates the external convex part to achieve that the block body downwards slides relative to the shell, the interlock piece is further taken to rotate and extends out of the first through hole, and the handcart is limited to move on the guide rail. By the electrical cabinet, the safety during operation of the user is improved, the fact that the handcart cannot be operated when a grounding switch is switched on is conveniently realized, the interlock requirement is achieved, and the safety of an operator is ensured.