知搜-全球专利检索

  1. 登录
  2. 注册
发明授权
CN106366216B 一种双活性磺酸基蔗渣木聚糖磺柳酸酯的合成方法 有权

一种双活性磺酸基蔗渣木聚糖磺柳酸酯的合成方法
摘要：
本发明公开了一种双活性磺酸基蔗渣木聚糖磺柳酸酯的合成方法。以蔗渣木聚糖为原料，在氨基三磺酸钠水相酯化法合成蔗渣木聚糖硫酸酯基础上，用磺柳酸与碳酸氢钠反应制备水杨酸‑5‑磺基酸钠作为后续酯化反应的羧酸酯化剂；以对甲基苯磺酸为催化剂，在甲苯溶剂中合成磺酸基蔗渣木聚糖磺柳酸酯钠盐；用稀硫酸将pH调至酸性，加入三倍的无水乙醇，抽滤得磺酸基蔗渣木聚糖磺柳酸酯粗产物；用丙酮和无水乙醇洗涤粗产品。本发明工艺简单，产品兼具蔗渣木聚糖磺柳酸酯和蔗渣木聚糖硫酸酯的性质，有较高的生物活性、良好的水溶性和较为完整的晶型结构。经过酯化改性后的蔗渣木聚糖硫酸酯即有更高的抗HIV活性，还有了抗炎、杀菌、抗肿瘤等活性。
摘要（英）：

The invention discloses a synthetic method of a double-activity sulfonate-based bagasse xylan salicylsulfonic acid ester. The synthetic method comprises the following steps of adopting bagasse xylan as a raw material, and utilizing salicylsulfonic acid and sodium bicarbonate to react for preparing salicylic acid-5- sulpho acid sodium as a carboxylic acid esterification agent for follow-up esterification reaction on the basis of synthesizing bagasse xylan sulphate through an amino sodium trisulfonic acid aqueous phase esterification method; adopting p-Methylbenzene sulfonic acid as a catalyst, and synthesizing sulfonate-based bagasse xylan salicylsulfonic acid ester sodium salt in a methylbenzene solvent; adopting dilute sulphuric acid to adjust pH to be acidity, adding three times of absolute ethyl alcohol, and carrying out suction filtration to obtain a sulfonate-based bagasse xylan salicylsulfonic acid ester crude product; washing the crude product through acetone and absolute ethyl alcohol. The synthetic method provided by the invention is simple in process, and the double-activity sulfonate-based bagasse xylan salicylsulfonic acid ester has the properties of bagasse xylan salicylsulfonic acid ester and the bagasse xylan sulphate, higher biological activity, favorable water solubility, and a relatively complete crystal structure. The bagasse xylan salicylsulfonic acid ester modified through esterification has higher anti-HIV activity, and other activities such as antiinflammation, sterilization and anti-tumor.

公开/授权文献
0/0