The invention relates to an energy-saving and loss-reduction analysis method of a macro positioning-micro searching sensitive source. When a theoretical line loss rate of a certain power supply area is over high, abnormal operation parameters or abnormal operation equipment is analyzed and reduced to analyze the influence degree thereof to the theoretical line loss of the area, and when a certain abnormal operation parameter or abnormal operation equipment is determines as the sensitive source that leads to the abnormal theoretical line loss of the area, a management scheme of the abnormal operation parameter or abnormal operation equipment is proposed, so that the theoretical line loss of the area is recovered. By implementation of the above-mentioned technical scheme, the method improves the pertinence of line loss treatment, reduces the fund investment of the line loss treatment and shortens the decision making time of the line loss treatment.