The invention discloses a grouting method of a nontoxic low-viscosity high-strength epoxy chemical grouting material. The grouting method comprises the following steps: (1) clearing the crack surface dirt to obtain a communicated crack; (2) arranging grouting holes; (3) closing the crack surface; (4) preparing a nontoxic low-viscosity high-strength epoxy chemical grouting slurry; (5) sequentially performing low-pressure grouting in holes one by one from bottom to top until all grouting holes are full; and (6) cleaning the grouting instrument by acetone. The method disclosed by the invention has good applicability to the stressed cracks of structural concrete, temperature cracks of mass concrete and differential settlement cracks of cavity lining concrete; and moreover, the components of the grouting material are nontoxic, the initial viscosity is low, the strength of the cured product is high, and the curing time is adjustable.