The invention discloses automatic drilling and tapping equipment which comprises a rack, a cam divider, a turntable, clamping jigs, jig locating devices, multi-head drilling machines, multi-head tapping machines, a material discharging device and material sensors, wherein the cam divider is mounted on the rack; the turntable is mounted on an output shaft of the cam divider; the turntable is divided into 4 to 8 stations; each clamping jig is mounted on each station of the turntable; the multi-head drilling machines, the multi-head tapping machines and the material discharging device are mounted on the rack in sequence along the stations in the circumferential direction of the turntable; the jig locating devices and the material sensors are mounted at the stations of the multi-head drilling machines and the multi-head tapping machines; a drill bit abnormity detection sensor is further arranged on each drill bit of each of the multi-head drilling machines; and a screw tap abnormality detection sensor and a thread detection sensor are further arranged on each screw tap of each of the multi-head tapping machines. The invention further provides an automatic drilling and tapping process. The automatic drilling and tapping equipment can replace a worker to realize automatic drilling and tapping, and is high in production efficiency, stable in quality and low in cost.