The invention discloses a receiving end buffer memory-based interference elimination and signal enhancement method and relates to the field of wireless network communication. The receiving end buffer memory-based interference elimination and signal enhancement method comprises the following steps: business content is cached on information receiving ends, and an information sending end obtains business content caching condition of a relevant information receiving end; when the information receiving end receives business content sent by the information sending end, whether the business content sent by the information sending end is what is needed by the information receiving end is determined according to business content which is locally cached; the business content which is cached locally is used as side information by the information receiving end, information of an information channel between the information receiving end and the information sending end is obtained, interference signals from the information sending end are subjected to interference elimination operation, the information receiving end simultaneously receives the business content sent by the information sending end and the same business content sent by other information sending ends, and therefore signal enhancement is realized. The method described in the invention can be used for fully tapping business attributes and user behavior characteristics so as to realize cross-layer interference elimination and signal enhancement, and network performance and system flexibility can be improved.