The invention belongs to the technical field of steel purification, and concretely relates to a production method of high-cleanliness IF steel. The production method comprises the following steps: 1, carrying out a converter process: controlling the content of carbon in molten steel to be 0.05-0.08 wt%, reducing the end point slag amount of the converter, and ensuring that the clearance height of ladles is 400-600 mm; 2, carrying out LF refining: adding 1-3 kg/t steel of active lime and 0.3-1.0 kg/t steel of CaC2 to the inlet of the LF, and carrying out submerged arc heating; 3, carrying out RH refining: carrying out RH decarburization treatment for 4-8 min, adding a molten steel advanced decarburization agent to a vacuum chamber, and adding a molten steel inclusion remover to the vacuum chamber in batches after alloyage ends; and 4, carrying out slab continuous casting: adopting a calcium aluminate tundish covering agent in the continuous casting process to obtain the high-cleanliness IF steel with the C content being not greater than 0.002 wt%. The method has the advantages of simplicity in operation, and low cost, allows the content of C in the final IF steel to be not greater than 0.002 wt%, the removal rate of inclusions with the particle size being not smaller than 20 [mu]m in the steel to be not lower than 80% and technical requirements for complete removal of inclusions with the particle size being not smaller than 50 [mu]m to be met, and realizes stable production of high-quality automobile panel steel.