The invention discloses a manual negative-pressure lifting and pressing external chest compression device and a use method thereof. The device comprises a compression plate and a screw connected to the bottom of the compression plate; the bottom of the compression plate is in threaded connection with a connecting seat through the screw; a rubber suction cup is arranged below the connecting seat. The device can be operated by one operator, the operator can place the rubber suction cup on the chest of a patient by holding a U-shaped handle tightly, when a miniature vacuum pump is started to pump out air in the rubber suction cup or the rubber suction cup is closely attached to the chest wall of the patient to extrude out the air in the rubber suction cup, negative pressure is formed in an inner cavity of the rubber suction cup, the rubber suction cup is adsorbed on skin of the chest of the rescued patient, and lifting and pressing are facilitated; the pressure in the chest is further reduced in the relaxing period of compression, then the pressure in the right atrium is further reduced until becoming the negative pressure, the returned blood volume is increased, the perfusion pressure of coronary arteries is increased, perfusion of blood of the coronary arteries and the blood of cardiac muscles is increased, oxygen metabolism of the cardiac muscles is accelerated, and the success rate of resuscitation is increased.