The invention discloses a preparation method of an anti-sticking black plastic eraser, and belongs to the technical field of stationery. An oyster shell is taken as a material to prepare an abrasive rich in calcium carbonate, the abrasive and nano titanium dioxide are compounded to prepare a compound filler, the compound filler is subjected to compound modification through natural resin shellac and microorganisms in methane, a resin particle is grafted on the surface of the filler, the compatibility and the combination force between the filler and a plastic substrate are improved, other materials are supplemented to perform mixing and hot pressing, and finally the anti-sticking black plastic eraser is obtained. The natural resin is used to modify the filler, and the problems of low product elasticity, poor erasing effect and the phenomenon of blackening, caused by poor compatibility between the filler and the plastic substrate of the common plastic eraser, are effectively solved.