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发明授权
CN106220496B 由α，β不饱和羧酸和苯丙酮类化合物直接合成含不饱和烯的α-酰氧基酮衍生物的方法 有权 转让

由α，β不饱和羧酸和苯丙酮类化合物直接合成含不饱和烯的α-酰氧基酮衍生物的方法
摘要：
本发明公开了一种由α，β不饱和羧酸和苯丙酮类化合物直接合成含不饱和烯的α‑酰氧基酮衍生物的方法，该方法是在空气环境下，α，β不饱和羧酸、苯丙酮类化合物及有机过氧化物，在铜化合物/四烷基季铵盐催化体系中，通过一锅反应合成含不饱和烯的α‑酰氧基酮衍生物；该方法首次通过α，β不饱和羧酸和苯丙酮类化合物直接合成含不饱和烯的α‑酰氧基酮衍生物，具有高选择性、高产率合、反应条件温和、步骤简单的特点，有利于工业化生产。
摘要（英）：

The invention discloses a method for directly synthesizing alpha-acyloxy ketone derivative containing unsaturated alkene from alpha, beta unsaturated carboxylic acid and a propiophenone compound. The method comprises the step of performing one-pot reaction on alpha, beta unsaturated carboxylic acid, the propiophenone compound and organic hyperoxide under an air environment in a copper compound/tetraalkyl ammonium salt catalytic system to synthesize the alpha-acyloxy ketone derivative. According to the method, the alpha-acyloxy ketone derivative is directly synthesized from the alpha, beta unsaturated carboxylic acid and the propiophenone compound for the first time. The method has the characteristics of high selectivity, high yield, mild reaction condition and simple step and is beneficial to industrial production.

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