The invention relates to the technical field of valves, in particular to an eccentric butterfly valve with an uninterrupted flange gasket sealing surface. The eccentric butterfly valve with the uninterrupted flange gasket sealing surface comprises a valve body, a valve plate, a valve body pressing plate, a valve seat, an upper valve shaft and a lower valve shaft; threaded holes are formed in the valve body and are formed out of an outer circle of the valve body; T-shaped grooves are formed in the valve body pressing plate and are formed out of the outer circle of the valve body pressing plate; socket head cap screws penetrate through the T-shaped grooves of the valve body pressing plate to connect to the threaded holes of the valve body; the valve seat is tightly clamped between the valve body and the valve body pressing plate; and the valve plate is in extruded contact with the valve seat to realize sealing of the valve. According to the eccentric butterfly valve with the uninterrupted flange gasket sealing surface, the socket head cap screws are arranged out of the outer circle of the valve body, so that the sealing contact surface position of a flange winding gasket and the valve is avoided; and therefore, the winding gasket for connecting the valve and a pipeline cannot be interrupted to cause a sealing failure, and the connection sealing between the valve and the pipeline is not influenced.