The invention provides an energy-saving environment-friendly ink cleaning agent and a preparation method thereof. The energy-saving environment-friendly ink cleaning agent is prepared from the following ingredients in percentage by mass: 4 to 10 percent of fatty acid alkyl ester, 2 to 4 percent of polyoxyethylated castor oil, 1 to 5 percent of alkaline inorganic matters, 3 to 6 percent of surface active agents, 0.2 to 0.6 percent of sodium metasilicate, 0.2 to 0.6 percent of sodium oxalate and the balance deionized water. The preparation method comprises the following steps that at normal temperature, firstly, the surface active agents and the alkaline inorganic matters are added into water; the mixture is sufficiently stirred, so that all ingredients are completly dissolved; then, the fatty acid alkyl ester, the polyoxyethylated castor oil, the sodium metasilicate and the sodium oxalate are added; the materials are stirred until the solution is transparent and clear; obtained uniform liquid is the water-base ink cleaning agent. The cleaning agent has the advantages that the environment friendly effect is achieved; the cleaning efficiency is high; the system stability is high; the anti-corrosion capability is high.