The invention discloses a high-yield grafting cultivation method of snakegourd fruits. Pumpkins are used as stocks for grafting, and dried fine soil is scattered on grafted seedlings in a seedling bed of a greenhouse; a small arch shed is erected and one layer of mulching film is flatly laid and is used for keeping heat and keeping moisture. The pumpkins are used as the stocks and the nutrient absorption ability of a root system of the pumpkins is relatively strong; the quantity of roots and an absorption area of the pumpkins greatly exceed those of the snakegourd fruits; the use amount of fertilizers in a snakegourd fruit cultivation process is reduced and the yield of the snakegourd fruits can also be improved; a humic acid solution is sprayed on the grafted seedlings so that the photosynthesis effect of the grafted seedlings is greatly accelerated; nutrients needed by the growth of the grafted seedlings is provided and the rapid growth of the grafted seedlings is facilitated; the snakegourd fruits obtained by the grafting cultivation method disclosed by the invention are large and the mouth feel is good; the problem of watermelon wilt is solved; the use of pesticides in a growing process can be reduced and green and environment-friendly requirements are met.