The invention discloses an esterification reaction production device for plasticizer production. The device comprises an ester storage tank, a second condenser, an esterification reaction kettle, an esterification tower, a first condenser, a primary alcohol-water separation tank, an extracting tank and an alcohol storage tank which are connected in sequence, wherein the primary alcohol-water separation tank is sequentially connected with a secondary alcohol-water separation tank and a water tank; the secondary alcohol-water separation tank and the water tank are both connected with the extracting tank; the alcohol storage tank is connected with the top of the esterification reaction kettle; a booster pump is arranged between the alcohol storage tank and the esterification reaction kettle; a valve is arranged between the booster pump and the esterification reaction kettle; and a capacity sensor is arranged inside the alcohol storage tank and is connected with a controller. According to the device disclosed by the invention, the capacity is greatly improved, the investment cost is reduced, the device operating efficiency is improved, the product conversion rate is improved, the energy consumption is reduced, and the equipment utilization rate and product yield are improved and stabilized.