The present invention discloses a solid-state fermentation method of artemisia annua. Firstly, each of raw materials is crushed, the crushed raw materials are mixed according to the following weight percentages: 50-60% of artemisia annua, 0-10% of soybean meal, 20-35% of wheat bran and 5-10% of corns, and then hot water at 35-40 DEG C is added to regulate the water content of the materials to be 45-50%; the temperature of the materials is 33-35 DEG C; and then a biological micro-organism liquid at 0.2-0.6% of the total weight of the materials is sprayed, the materials are fermented at a temperature of 32-45 DEG C for 4-6 d, the fermented materials are dried or sun-dried, and the dried materials are crushed to obtain fermentation products. The accessory materials and micro-organism fermentation are used to solve the problems that the artemisia annua is bitter in tastes and mellow in fragrance, and the active ingredients are difficult to fully release. Through the micro-organism degradation function, the effective components and the active substances of the artemisia annua are released to the maximum. Besides, through experiments, it is also found that the probiotics promote the fermentation of the artemisia annua, and at the same time, the artemisia annua also does not kill the probiotics, but on the contrary also extends the survival time of the probiotics.