The invention discloses a preparation process of polyurethane resin compound glue for reflective garments. The preparation process is characterized by including steps: 1) adopting sebacic acid as acid for synthesizing polyhydric alcohol, and adopting isophthalic acid for substituting for a small part of sebacic acid, wherein the synthesized polyhydric alcohol with the molecular weight being 1000 is named PSI; 2) synthesizing polyhydric alcohol with adipic acid and sebacic acid as main materials, wherein the synthesized polyhydric alcohol with the molecular weight being 3000 is named PSA; 3) feeding the polyhydric alcohol PSI and the polyhydric alcohol PSA, completely melting at 70 DEG C, feeding a chain extender and an antioxidant, and stirring. The preparation process of the polyurethane resin compound glue for the reflective garments has advantage that the resin compound glue used for adhesion of fabrics and reflective materials makes the garments remarkable in high-temperature washing resistance after adhesion.