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发明公开
CN106008523A 作为TRK激酶抑制剂的被取代的吡唑并[1,5-a]嘧啶化合物 失效 - 权利终止

作为TRK激酶抑制剂的被取代的吡唑并[1,5-a]嘧啶化合物
摘要：
式I的化合物和其盐，其中R1、R2、R3、R4、X、Y和n具有本说明书给定的含义，为Trk激酶的抑制剂并用于治疗疾病，该疾病可用Trk激酶抑制剂治疗，如疼痛、癌症、炎症、神经退行性疾病和特定的感染疾病。
摘要（英）：

Compounds of Formula (I) and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.

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