The invention provides a preparation method of a Bi-2212 superconducting wire/strip. The method comprises the following steps that 1) Bi-2212 precursor powder is placed in a heat treatment furnace to remove air; 2) the Bi-2212 precursor powder is pretreated; 3) the Bi-2212 precursor powder is filled into a hydraulic tube in a vibration manner; 4) isostatic pressing molding is carried out to obtain a rod base, the rod base is mounted in a silver tube, the two ends of the silver tube are sealed, and a Bi-2212 single-core complex is obtained; 5) bundle-drawing is carried out on prepared single-core wires to obtain a Bi-2212 multi-core wire; and 6) heat treatment is carried out to obtain the Bi-2212 superconducting wire, or heat treatment is carried out after rolling to obtain the Bi-2212 superconducting strip. According to the invention ,the problem that a silver super interface is unsmooth and low in processing uniformity in the processing process can be solved effectively, and the current carrying performance of the Bi-2212 superconducting wire/strip is improved substantially.