The invention discloses an anti-collision treasure box. The anti-collision treasure box comprises a box body provided with a box cover; a one-way valve air cock is arranged on the box cover; more than one support pad assembly is respectively arranged on each of the box cover and the box body; each support pad assembly includes a support pad seat, and an air bag fixed on the support pad seat; through holes are formed in the support pad seats; one ends of the through holes are communicated with the atmosphere, and the other ends are communicated with the air bags; and the airbags are corresponding to an internal space of the box body. The anti-collision treasure box combines the support pad assemblies with the vacuum box body, adopts the one-way valve air cock to vacuumize the box body, the air bags of the support pad assemblies swell under the effect of atmospheric pressure, a buffer area is formed between goods and a box wall, the collision problem in transportation of fragile goods is solved, objects needing vacuum protection can also be preserved, and the anti-collision treasure box has such characteristics as firm structure, simple operation, reusability, moisture prevention and bacteria prevention.