The invention discloses a carton binding machine capable of binding in rows. The carton binding machine comprises a base, a vertical column, a cross beam and a carton bracket, wherein the vertical column is arranged perpendicular to the base, and the cross beam and the carton bracket are perpendicularly arranged on the vertical column. The cross beam is arranged at the top end of the vertical column and parallel to the base. The carton bracket is located under the cross beam and parallel to the cross beam. One side surface of the cross beam is provided with a sliding rail arranged in the axial length direction of the cross beam. A plurality of sliding blocks are installed on the sliding rail. A binding machine head is installed on the bottom surface of each sliding block. At least one side edge of the sliding rail is provided with a plurality of concave holes distributed in rows in the axial length direction of the cross beam. Each sliding block is provided with plug pin rods which can be inserted in the concave holes. The bottom surface of the cross beam is provided with a guide strip which is arranged in the axial length direction of the cross beam and parallel to the cross beam. The guide strip is hung on the cross beam through a spring and close to the carton bracket under the binding machine heads. The bottom surface of the guide strip makes contact with a carton in an abutting mode when the carton is placed on the carton bracket. According to the carton binding machine capable of binding in rows, binding in rows is achieved, the binding distance is flexibly adjusted, and a guidance instruction is provided for the binding position.