The invention discloses a production process for odor-resistant antibacterial leather. The production process comprises the following steps: de-fatting, neutralizing, dyeing, heating and stuffing, solidifying acid, carrying out odor-resistant antibacterial treatment, bloating and standing, and drying and milling, thereby obtaining the odor-resistant antibacterial leather. According to the production process, anionic dye and an anionic type stuffing agent to solidify acid, and a cationic type antibacterial agent and a cationic type color fixing agent can be used for increasing the bonding strength of the material after water washing, so that material transfer is avoided.