The invention discloses a pharmaceutical reaction kettle, mainly comprising a medium-pressure bushing, a reaction kettle, heat exchangers and a gas compressor, wherein the reaction kettle consists of an upper end cover, a fixed kettle body, a pressurizer, a rotary kettle body and a back heating tank, a photoscope is installed on the upper end cover, the pressurizer is installed between the fixed kettle body and the rotary kettle body, a heat exchange is installed at each of two sides of the outer wall of the rotary kettle body of the reaction kettle, the back heating tank is installed at the lower part of the rotary kettle body, and a pressure reducer is installed at the outer side of the back heating tank. According to the pharmaceutical reaction kettle disclosed by the invention, the rotary kettle body is provided, reagent is generated in the rotary kettle body, and the pharmaceutical reaction kettle has a good heat radiating effect while it is easy to produce heat during the preparation process of conventional biological reagents.