The invention relates to a method for intensive cultivation of ictalurus punctatus. The method comprises a step (1) of performing fingerling cultivation, a step (2) of performing adult fish cultivation, a step (a) of having pond conditions; a step (b) of performing preparation prior to stocking; a step (c) of performing stocking of fingerlings; a step (d) of feeding baits: adopting mixed domestication feeding of compound pellet feed and Chinese herbal medicine baits; a step (e) of performing daily management, and timely increasing the feeding amount of the Chinese herbal medicine baits by 15-20% of an original usage amount when fish disease is found. The Chinese herbal medicine baits are prepared from, by weight parts, 3-5 parts of nucleic acid yeast extract, 0.5-1 part of multi-vitamins, 10-15 parts of Chinese herbal medicine extract, 40-60 parts of enteric soluble polymers and 5-8 parts of vitamin E acetic ester. The Chinese herbal medicine baits used in the cultivation method are reasonable in compatibility, balanced in nutrition and low in processing cost, can remarkably improve immunity of ictalurus punctatus and greatly reduce the probability of edwardsienosis infection of ictalurus punctatus, is free of drug residue, leads to no drug resistance and is high in safety.