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CN105801682A 一种抗肿瘤多肽GRNA的制备方法及其在肿瘤治疗/预防中的应用 无效 - 撤回

一种抗肿瘤多肽GRNA的制备方法及其在肿瘤治疗/预防中的应用
摘要：
本发明涉及一种来源人Progranulin（PRGN）基因编码的小分子多肽的制备方法和应用。抗肿瘤多肽GRN A的制备方法及应用，属于生物医学领域。本发明所述的GRN A是一种小分子多肽，由58个氨基酸残基组成的多肽，命名为GRN A。本发明通过毕赤酵母真核表达体统表达纯化出纯度较高的GRN A。重组人GRN A可以抑制多种肿瘤细胞的生长，诱导肿瘤细胞凋亡，杀死肿瘤细胞，在开发抗肿瘤药物方面有很大应用价值。
摘要（英）：

The invention belongs to the field of biological medicine, and relates to a preparation method and application of micro-molecule polypeptide of human Progranulin (PRGN) gene coding, in particular to a preparation method and application of anti-tumor polypeptide GRN A.The GRN A is a micro-molecule polypeptide, composed of 58 amino acid residues and named as GRN A.The GRN A with the high purity is purified through expression of a pichia pastoris eukaryotic expression vector.The recombination human GRN A can restrain growth of various tumor cells, induce tumor cell apoptosis, kill tumor cells, and have the great application value in the aspect of developing anti-tumor medicines.

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