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发明公开
CN105801602A 5-叔丁基异噁唑-3-基-3-(4-取代苯基)脲衍生物及其制备方法和用途 有权

5-叔丁基异噁唑-3-基-3-(4-取代苯基)脲衍生物及其制备方法和用途
摘要：
本发明属于化学医药领域，具体涉及5-叔丁基异噁唑-3-基-3-(4-取代苯基)脲衍生物及其制备方法和用途。本发明提供了一种5-叔丁基异噁唑-3-基-3-(4-取代苯基)脲衍生物，其结构如式Ⅰ所示。本发明还提供了5-叔丁基异噁唑-3-基-3-(4-取代苯基)脲衍生物的制备方法和用途。本发明在大量筛选的基础上得到上述的5-叔丁基异噁唑-3-基-3-(4-取代苯基)脲衍生物，具有抑制人急性髓性白血病细胞增殖的活性，为治疗急性髓性白血病药物的开发和应用提供了新的选择。
摘要（英）：

The invention belongs to the field of chemical medicines and relates to a 5-tert-butylisoxazole-3-yl-3-(4-substituted phenyl)urea derivative and its preparation method and use. The 5-tert-butylisoxazole-3-yl-3-(4-substituted phenyl)urea derivative is shown in the structural formula I. The invention also provides a preparation method and a use of the 5-tert-butylisoxazole-3-yl-3-(4-substituted phenyl)urea derivative. The 5-tert-butylisoxazole-3-yl-3-(4-substituted phenyl)urea derivative obtained through massive screening has human acute myeloid leukemia cell proliferation inhibition activity and provides a novel choice for development and use of a drug for treating acute myeloid leukemia.

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