The invention discloses a phosphorite reverse flotation tailings conveying pipe antisludging agent and a preparation method and application thereof.The phosphorite reverse flotation tailings conveying pipe antisludging agent is characterized by being formed by uniformly mixing, by mass, 60-80% of fatty acid methyl ester ethoxylate sulfonate and 20-40% of sodium polyacrylate.Water is added to the phosphorite reverse flotation tailings conveying pipe antisludging agent at the temperature of 40-50 DEG C, so that a solution with the mass concentration being 1%o is obtained, the solution is added to a tailings conveying pipe, and the adding amount of the phosphorite reverse flotation tailings conveying pipe antisludging agent is 5-10 PPM of the mass of tailings.After the phosphorite reverse flotation tailings conveying pipe antisludging agent is used, the operation cycle of a tailings conveying pipe system is prolonged from 180 days to the existing 980-1180 days, under the condition that conveying capability is not changed, the cleaning cycle of the tailings conveying pipe is prolonged, cleaning time is shortened, and the operation rate of a device is raised.The antisludging agent solution is easy to compound and more convenient and economical to use.