The invention discloses a formaldehyde-removing and deodorizing ferment smell-cleaning agent, which is prepared from culture solutions of the following microorganisms: Issatchenkia orientalis, Lactobacillus paracasei, Pediococcus pentosaceus and Saccaromyces cerevisiae. The smell-cleaning agent has inherent luster and fragrance, does not have peculiar smell and odor, is negative in terms of coliform, does not contain any toxic ingredients, can directly adsorb, wrap, decompose and clean off various toxic substances existing in daily home life from the source of peculiar smell, and has a strong deodorization effect, and in particular, the formaldehyde degradation and removal rate can reach 99 percent or more than 99 percent.