The invention discloses an industrialized fry breeding method for marine oncorhynchus mykiss. The method comprises steps as follows: (1), hatching: eyed eggs are hatched in an indoor fresh water flowing manner, and a hatching room keeps dark; (2), breeding of fish larvae and juveniles: the fish larvae and juveniles are bred in the indoor fresh water flowing manner, the water temperature is kept in a range from 10 DEG C to 14 DEG C, the new water addition amount of a single pool is 10-15 L/min/10,000 fish larvae and juveniles, and the breeding density in the water flowing mode does not exceed 15 kg/m<3>; (3), fry breeding: the marine oncorhynchus mykiss fries are bred by adopting indoor closed circulating fresh water, the water temperature is kept in a range from 14 DEG C to 18 DEG C, the water circulating amount of a circulating water breeding pool is 15-25 times/day/pool, the illumination intensity is kept in 800-1,000 lux, and the 24 hours of illumination intensity is kept. The fry breeding process of the marine oncorhynchus mykiss is performed indoors and is not influenced by weather, year-round production can be realized, the water quality condition is stable and controllable, the survival rate of the bred fries is high, and high-density large-scale breeding can be realized.