The invention relates to a method for synthesizing diisoamyl oxalate by using a particle immobilized catalyst, comprising: using oxalic acid and isoamyl alcohol as materials, adding an immobilized catalyst prepared by particle tangling forming process, and synthesizing in a reactor, diisoamyl oxalate; after reacting, removing the particle immobilized catalyst online without cooling, and rectifying and purifying a product; or separating and recycling residual excessive isoamyl alcohol in a reaction liquid, and removing the particle immobilized catalyst.The method has the advantages that the step of removing the catalyst from the reaction liquid is simplified, post-treatment cost is reduced, and conditions are provided for removing the catalyst online without cooling; side reactions in reaction later stage and separation phase are inhibited, product quality is improved, and activity of the catalyst is protected; reaction catalytic activity is high, the catalyst is reusable, the product is easy to separate, the production process is simplified, and production cost is lowered.