The invention discloses a medicine for alleviating municipal sewage pipeline blocking and application of the medicine. The medicine is prepared from the following components in percentage by mass: 20-40% of a quorum sensing inhibitor, 30-50% of a surfactant and 20-30% of a solubilizer, wherein the quorum sensing inhibitor consists of the following components mixed in percentage by mass: 40-60% of meta-bromo-thiolactone, 20-30% of bromination furanone and 10-30% of AIP compounds. The quorum sensing inhibitor is taken as a main component, the quorum sensing behavior of microorganisms in a sewage pipeline can be inhibited, and thus the microorganisms can be prevented from forming biological membranes to block the sewage pipeline.