The invention discloses preparation and application of targeted mitochondrion nano particles on the basis of a composite porcelain body. With a nano porcelain body as a drug carrier, the drug is embedded in a self-assembly manner, wherein target small molecules modify the surface of the embedded drug. The nano porcelain body has stable structure and has time stability and structural stability. The drug in the nano porcelain body can be slowly released. After the surface is modified by the target small molecules, the nano particles can be slowly released in a targeted manner, so that excellent targeted organelle effect is achieved by means of the nano particles in cells. The nano particles have important application significance on the chronic diseases, such as Parkinson's Disease, cancers, and the like, which require long-time therapy.