The invention relates to a bulk pharmaceutical chemical production technology, in particular to a novel rifamycin SV sodium salt production technology.A W/O emulsion liquid membrane is extracted from fermentation broth, and rifamycin SV sodium is directly generated.The content of the product obtained by means of the production technology is 90-97%, and water content is 2.6-5%.The technological process is short, three-waste output is low, raw material consumption is low, the yield of rifamycin SV sodium is effectively increased, and the problems of existing technologies that the technological process is long, impurity content is high and yield is low are solved.The novel rifamycin SV sodium salt production technology has great significance in promoting industrial development and has broad industrialized application prospects.