The invention relates to a solvent-free washing and drying technology for 6-APA (6-aminopenicillanic acid) and belongs to the technical field of pharmaceutical chemicals. The solvent-free washing and drying technology for 6-APA is realized through operation including centrifugal filtration, microwave drying and the like, use of flammable and explosive acetone is avoided, the production cost is reduced, and potential safety risks are eliminated. Meanwhile, acetone wastewater is not produced, acetone is not required to be recovered through distillation with a distillation column, use amount of steam is reduced, and energy consumption is reduced; besides, the distillation column is not required to be used, acetone residues are not produced, the total discharge capacity of a workshop is reduced, and emission reduction from the source is realized.