A target set of one or more audio samples is automatically expanded to include one or more additional audio samples or sets of audio samples. Multiple different audio samples or sets of samples that have a high compatibility rating with the target set are identified. The high compatibility rating is based on rhythmic compatibility with the target set, harmonic compatibility with the target set, and/or compatibility with various other characteristics or parameters of the target set. One or more of the audio samples or sets of audio samples having a high compatibility rating with the target set are automatically added to the target set. Thus, the user is able to have a set of audio samples automatically added to a particular target set of audio samples, resulting in an expanded set of audio samples that sound coherent (e.g., rhythmically and harmonically compatible).