The invention discloses a power supply circuit design method based on an OpenPOWER platform, and relates to the power circuit design technology. Inner core voltage and caching voltage of a CPU can be controlled and adjusted in real time by means of an SPIVID interface, a programmable chip PSOC and a power supply control chip of the CPU; the programmable chip PSOC and the CPU are in interaction through the SPIVID interface, VID control information of the CPU is converted into PVID control information, the power supply control chip adjusts and outputs the pulse signal PWM duty ratio according to the PVID control information, and the output voltage of a power supply driving chip is controlled in real time. By means of the PSOC and the power supply control/driving chip, the inner core voltage and the caching voltage of the CPU can be controlled asynchronously at the same time.