A semi-regeneration catalytic reforming reaction system comprises at least one combined bed reactor and a fixed bed reactor connected with the combined bed reactors in series.Each combined bed reactor is formed by combination of a fixed bed and a tube nest type fixed bed catalyst bed, wherein in the tube nest type fixed bed catalyst bed, the outlet material flow of the follow-up fixed bed reactor makes indirect contact with the reaction material flow of the combined bed reactor and heat is provided.The invention further provides a catalytic reforming method adopting the system.The problem that the operation efficiency of a reforming reaction system is hard to improve due to the limitation of the regeneration period of a catalyst of a final reactor can be well solved, and the reforming reaction system is made to obtain higher operation benefits.