Toilet assemblies having various embodiments of a cleaning system are described herein which include a toilet assembly and a cleaning system. The toilet assembly has a toilet bowl, a toilet tank, a flush valve, a rim inlet port and a rim flow path (which may be an isolated rim path) extending from an outlet of the flush valve to the rim inlet port. The cleaning system has a reservoir for holding a liquid cleaning agent having an outlet port in fluid communication with the interior space of the reservoir body; a housing to receive the reservoir; a supply conduit in fluid communication with the interior of the reservoir; a flow control device capable of controlling flow through the supply conduit; and a control system activatable by an actuator feature, wherein upon activation of the actuator feature, the control system is adapted to initiate a clean cycle by: operating the flow control device for a first period of time sufficient to deliver a dose of a liquid cleaning agent from the supply conduit to an interior space of the flush valve in a closed position, the flush valve configured for delivery of fluid to the rim inlet port, and operating the flush valve to open the flush valve to introduce flush water to carry the dose of a liquid cleaning agent through the rim inlet port into the toilet bowl.