The invention provides a liftable loading mechanism and a shear-seepage coupling testing device applying the same. The liftable loading mechanism comprises an underframe, a longitudinal loading mechanism and a lateral loading mechanism, wherein a testing region is positioned at the upper side of the underframe; the longitudinal loading mechanism is fixed above the testing region of the underframe and is of a liftable structure integrally; the lateral loading mechanism is fixed above the testing region of the underframe, is of a liftable structure integrally and is staggered from the longitudinal loading mechanism; when being used for transporting a two-dimensional rock sample, the longitudinal loading mechanism and the lateral loading mechanism ascend; after the two-dimensional rock sample is transported to the testing region, the longitudinal loading mechanism and the lateral loading mechanism descend, and apply a longitudinal force and a lateral force to the two-dimensional rock sample transported to the testing region. According to the liftable loading mechanism and the shear-seepage coupling testing device, the longitudinal loading mechanism and the lateral loading mechanism are set to be liftable, and ascend when being used for transporting the two-dimensional rock sample; during testing, the longitudinal loading mechanism and the lateral loading mechanism descend, thus realizing simple and effective loading of the two-dimensional rock sample.