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发明授权
CN105535975B 囊泡相关膜蛋白1在防治肠道病毒71型感染中的应用 失效 - 权利终止

囊泡相关膜蛋白1在防治肠道病毒71型感染中的应用
摘要：
本发明涉及生物医学技术领域，是一种抗肠道病毒71型感染的新靶点及应用。本发明以人神经母细胞瘤细胞(SH‑SY5Y)作为靶细胞，采用RNA干扰技术下调靶细胞宿主蛋白的表达，来寻找可有效抑制EV71感染人神经母细胞瘤细胞(SH‑SY5Y)的宿主因子，预防病毒感染中枢神经系统及减少对神经系统的损害。本发明通过实验发现囊泡相关膜蛋白1(vesicle‑associated membrane protein 1，VAMP1)在EV71感染SH‑SY5Y中发挥着重要的作用，下调VAMP1的表达，能明显抑制EV71的感染。本发明提供了VAMP1在制备预防或治疗肠道病毒71型感染药物中的应用。
摘要（英）：

The invention relates to the technical field of biomedicine, and particularly relates to a novel target preventing enterovirus 71 infection and applications thereof. Through adopting a human neuroblastoma cell (SH-SY5Y) as a target cell, and reducing expression of target cell host protein by adopting an RNA interference technique, a host factor effectively inhibiting EV71 infection of the human neuroblastoma cell (SH-SY5Y) is searched so as to prevent central nervous system virus infection and reducing damage to the nerve system. Experiments show that vesicle-associated membrane protein 1 (called as VAMP1 for short) plays an important role in EV71 infection of the human neuroblastoma cell (SH-SY5Y) and EV71 infection can be obviously inhibited by reducing expression of the VAMP1. The invention provides applications of the VAMP1 in preparation of medicines preventing and treating the enterovirus 71 infection.

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