The invention discloses a multi-mode resin mixture transfer process test bed and a method for simulating vacuum transfer test therewith. The test bed comprises a first resin mixture storage tank, a second resin mixture storage tank, vacuumizing branches respectively connected with the first resin mixture storage tank and the second resin mixture storage tank, a resin mixture transfer tank, a resin mixture flushing and draining tank, a resin mixture mixing tank, a pipeline system for connecting them, and a console. According to the multi-mode resin mixture transfer process test bed and the method, the structure is reasonable, technological processes of vacuum transfer and hydraulic displacement for resin mixture transfer can be effectively completed, and powerful test data and parameter verification can be provided for integrated design of a shielding transfer device; meanwhile, fluidity tests on mixtures different in density, such as resin, zeolite and activated carbon under different ratios are performed, practical guiding significance is achieved for solid coarse particle mixture pipeline transportation, and the test bed and the method can be used in wider fields.