The invention discloses curvature-variable bending equipment for a skylight guide rail. The curvature-variable bending equipment comprises a rack, a control device, a regulating system, a man-machine interaction system, a power device, an upper molding board and a lower molding board, wherein the man-machine interaction system is connected to a control system; the control system is connected to a regulating system through a power device; the regulating system comprises a plurality of groups of curvature regulating assemblies which are arranged side by side; each curvature regulating assembly comprises a curvature plate with a long-strip-shaped structure; the upper molding board made of a plastic material is arranged below the curvature plate; the lower molding board made of the plastic material is correspondingly arranged below the upper molding board; and the upper molding board and the lower molding board are connected to the rack through the power device. The man-machine interaction system is used for displaying the state and the curvature of the equipment, and an operator can control the equipment through the man-machine interaction system. The curvature-variable bending equipment adopts digital control for digitizing positions of movable parts in the equipment, so that the bending curvature of a product can be controlled more precisely.