The embodiment of the invention discloses a full-automatic regional citrate anticoagulation (RCA) machine which includes a sampling portion, a sample-injection portion, a test analysis portion, an administration portion, and a program control portion. The sampling portion extracts a blood sample on line and in real time and sends the blood sample to a blood sample storage purifier for storage and purification. The sample-injection portion conveys the blood sample in blood storage purifier through a sample injection tube to a sample-loading slot. The test analysis portion conveys the blood sample through a sample suction tube to an analysis meter for blood sample test and analysis. The sampling portion, the sample-injection portion, the test analysis portion and the administration portion are connected to the program control portion. The program control portion controls the sampling portion, the sample-injection portion and the test analysis portion to work according to an internal set program, and sends an instruction to the administration portion according to the data result obtained from the test analysis portion. The technical problems that manual operation and operation steps are tedious and time-consuming, the time for adjusting the administration dosage is delayed, and the charge is expensive in the RCA method in the prior art are solved.