The invention discloses a fast-dehydrating curable and organic synthetic plugging agent compound plugging construction method. The method sequentially includes the steps of preconstruction preparation, preparation of plugging slurry, injection and squeezing of the plugging slurry, and plug sweeping after plugging. For injection and squeezing of the plugging slurry, different modes are selected to perform squeezing injection plugging according to different conditions. The method is applicable to site construction of plugging by compounding fast-dehydrating curable plugging agents and organic synthetic plugging agents, the problem that the compound plugging agent easily settles and accumulates at the bottoms of slurry forming tanks to block pipelines or jam drilling tools when used in the prior art is solved, and safety in construction is assured.