The invention discloses an infrared scalpel handle system. The infrared scalpel handle system comprises a scalpel handle pre-warning device and a sound-light alarm device. After a surgery is finished, a human body is to be closed, emitted infrared rays can be completely blocked, then a signal discrimination chip in the scalpel handle pre-warning device sends out an alarm command, and the sound-light alarm device is started to produce tweeting sounds and light a lamp, so that a medical worker is reminded. The infrared scalpel handle system has the function of producing alarm sounds when the scalpel is left in the human body, and medical malpractice can be avoided.