The invention relates to an inkjet printer nozzle cleaning device. The inkjet printer nozzle cleaning device comprises a cleaning bottle filled with cleaning liquid; a water outlet pipe of the cleaning bottle is connected with a water inlet of a pump; a water outlet of the pump is connected with a first water inlet pipe of a three-way valve; a second water inlet pipe of the three-way valve is connected with an ink way system of an inkjet printer; a water outlet pipe of the three-way valve is communicated with a water inlet pipe at the bottom of an aeration disc; the aeration disc is provided with an air inlet pipe; an air inlet of the air inlet pipe is connected with an air outlet of an air blower; the aeration disc is mounted at the bottom of a cleaning disc. During cleaning, a nozzle to be cleaned is put in the cleaning disc, the three-way valve is adjusted, the second water inlet pipe is closed, the first water inlet pipe is opened, and the pump is started to extract the cleaning liquid in the cleaning bottle to clean the nozzle; the air blower continuously blows bubbles during cleaning, the cleaning liquid is mixed with blown air in the aeration disc, the contact area between the cleaning liquid and the nozzle can be increased due to rolling bubbles on the cleaning liquid, and the surface of the nozzle is stressed in multiple directions, so that the nozzle is easier to clean.