The invention discloses a Fe3O4 magnetic nimodipine liposome. The Fe3O4 magnetic nimodipine liposome is formed by combining polyethylene glycol-modified Fe3O4 nano particles onto the surface of a drug-carrying liposome, the diameter is about 100-200 nm, the morphology is regular, and black magnetic particles exist on the surface of the liposome to form the nano liposome which has the magnetic targeting property and can easily pass through a blood brain barrier. A preparation method of the magnetic liposome mainly comprises the steps that nimodipine, soybean lecithin and cholesterol are dissolved in ethyl alcohol, then the materials are added into a hydration medium phosphate buffer solution, absolute ethyl alcohol is removed through rotary evaporating or stirring, and then the nimodipine nano liposome is obtained; FeSO4.7H2O and FeCl3.6H2O are dissolved in ultrapure water according to the mole ratio of 1:2, polyethylene glycol-2000 is added, and polyethylene glycol-2000-modified Fe3O4 nano particles are prepared through a coprecipitation method; the liposome solution and a Fe3O4 aqueous solution are mixed according to a certain ratio, and then the Fe3O4 magnetic nimodipine liposome is obtained through incubation. According to the Fe3O4 magnetic nimodipine liposome and the preparation method thereof, operation is easy, the reaction is easy to control, the repeatability is high, and the yield is high.