The invention discloses a dexmethylphenidate skeleton pattern transdermal patch containing a vitiligo inhibitor and a preparing method thereof. The transdermal patch comprises a skeleton pattern adhesive layer, wherein the skeleton pattern adhesive layer comprises dexmethylphenidate or hydrochloride thereof, the vitiligo inhibitor and an adhesive, the vitiligo inhibitor contains one or more of titanium dioxide, tartaric acid, tretinoin, trichloroacetic acid, zinc oxide, hydroxyl dimethoxy phenylmalonate diethyl hexyl ester and ectoin, and the weight ratio of the vitiligo inhibitor is 5-15%. By the adoption of the transdermal patch, curative effect is guaranteed, and perpetual skin vitiligos are prevented from being generated; the efficacy of the preparation is improved, children clinical medication risks are reduced, and the safety of the preparation is fully guaranteed. The transdermal patch is simple in composition, the technology is simple and easy to apply, cost is low, and production is highly efficient.