The invention relates to the field of intelligent cabinets, in particular to a control method and a control system of a drawer cabinet. Cases of the drawer cabinet are opened and closed by means of an open and close control module of a drive circuit, an open and close translational device and a case position detector of a drive device and other corresponding devices. The cases of the cabinet are stopped automatically once external pressure applied to the cases during moving is detected through a pressure detecting module of the drive circuit, and thus, damage and collision accidents are avoided. Further, position and state of the cases are detected in time by cooperation of a case state detecting module of the drive circuit and a case position detecting module of the drive device, and can be fed to the system in time to facilitate determination making. Intelligently opening and closing of the cases of the cabinet are achieved substantially with high safety by the control method and the control system of the drawer cabinet.